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Can I read FGF401 and vinorelbine synergistically mediate antitumor activity and vascular normalization in FGF19-dependent hepatocellular carcinoma on EtoBox?
FGF401 and vinorelbine synergistically mediate antitumor activity and vascular normalization in FGF19-dependent hepatocellular carcinoma by Huynh, Hung; Prawira, Aldo; Le, Thi Bich Uyen; Vu, Thanh Chung; Hao, Huai-Xiang; Huang, Alan; Wang, Youzhen; Porta, Diana Graus is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is FGF401 and vinorelbine synergistically mediate antitumor activity and vascular normalization in FGF19-dependent hepatocellular carcinoma about?
Hepatocellular carcinoma (HCC) is a lethal cancer with limited therapeutic options, and standard therapy with sorafenib provides only modest survival benefits. Fibroblast growth factor 19 (FGF19) has been proposed as a driver oncogene, and targeting its receptor, FGFR-4, may provide a better alternative to standard therapy for patients with FGF19-driven tumors. Sixty-three HCC patient-derived xenograft (PDX) models were screened for FGF19 expression. Mice bearing high and low FGF19-expressing tumors were treated with FGF401 and/or vinorelbine, and the antitumor activity of both agents was assessed individually and in combination. Tumor vasculature and intratumoral hypoxia were also examined. High FGF19 expression was detected in 14.3% (9 of 63) of the HCC models tested and may represent a good target for HCC treatment. FGF401 potently inhibited the growth of high FGF19-expressing HCC models regardless of __FGF19__ gene amplification. Furthermore, FGF401 inhibited the FGF19/FGFR-4 signaling pathway, cell proliferation, and hypoxia, induced apoptosis and blood vessel normalization and prolonged the overall survival (OS) of mice bearing high FGF19 tumors. FGF401 synergistically acted
Who reads FGF401 and vinorelbine synergistically mediate antitumor activity and vascular normalization in FGF19-dependent hepatocellular carcinoma?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Huynh, Hung; Prawira, Aldo; Le, Thi Bich Uyen; Vu, Thanh Chung; Hao, Huai-Xiang; Huang, Alan; Wang, Youzhen; Porta, Diana Graus
- Publisher
- Korean Society of Medical Biochemistry and Molecular Biology; Springer Science and Business Media LLC; Nature Publishing Group; Seoul: Korean Society of Medical Biochemistry and Molecular Biology, 2009 (ISSN 1226-3613)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)