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Can I read CATs and HATs: the SLC7 family of amino acid transporters on EtoBox?
CATs and HATs: the SLC7 family of amino acid transporters by Franois Verrey; Ellen I. Closs; Carsten A. Wagner; Manuel Palacin; Hitoshi Endou; Yoshikatsu Kanai is a Medicine article available to read on EtoBox.
What is CATs and HATs: the SLC7 family of amino acid transporters about?
The SLC7 family is divided into two subgroups, the cationic amino acid transporters (the CAT family, SLC7A1-4) and the glycoprotein-associated amino acid transporters (the gpaAT family, SLC7A5-11), also called light chains or catalytic chains of the hetero(di)meric amino acid transporters (HAT). The associated glycoproteins (heavy chains) 4F2hc (CD98) or rBAT (D2, NBAT) form the SLC3 family. Members of the CAT family transport essentially cationic amino acids by facilitated diffusion with differential trans-stimulation by intracellular substrates. In some cells, they may regulate the rate of NO synthesis by controlling the uptake of l-arginine as the substrate for nitric oxide synthase (NOS). The heterodimeric amino acid transporters are, in contrast, quite diverse in terms of substrate selectivity and function (mostly) as obligatory exchangers. Their selectivity ranges from large neutral amino acids (system L) to small neutral amino acids (ala, ser, cys-preferring, system asc), negatively charged amino acid (system x(c)(-)) and cationic amino acids plus neutral amino acids (system y(+)L and b(0,+)-like). Cotransport of Na(+) is observed only for the y(+)L transporters when they ca
Who reads CATs and HATs: the SLC7 family of amino acid transporters?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Franois Verrey; Ellen I. Closs; Carsten A. Wagner; Manuel Palacin; Hitoshi Endou; Yoshikatsu Kanai
- Publisher
- Springer Science and Business Media LLC
- Published
- 2004
- Language
- EN
- Field
- Medicine (Life Sciences)