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Platelet-derived Growth Factor-coated Decellularized Meniscus Scaffold for Integrative Healing of Meniscus Tears by Il Lee, Kwang; Olmer, Merissa; Baek, Jihye; D'Lima, Darryl D.; Lotz, Martin K. is a Engineering article available to read on EtoBox.

What is Platelet-derived Growth Factor-coated Decellularized Meniscus Scaffold for Integrative Healing of Meniscus Tears about?

## Statement of significance: Meniscus tears are the most common injury of the knee joint. the most prevalent forms that occur in the inner third typically do not spontaneously heal and represent a major risk factor for the development of knee osteoarthritis. the goal of this project was to develop an approach that is readily applicable for clinical use. we selected a natural and readily available decellularized meniscus scaffold and conjugated it with pdgf, which we had previously found to have strong chemotactic activity for chondrocytes and progenitor cells. the present results show that insertion of the pdgf-conjugated scaffold in defects in avascular meniscus led to endogenous cell migration and proliferation into the defect zone with tissue integration between the scaffold and injured explants and improved tensile properties. this pdgf-conjugated scaffold will be promising for a translational approach to healing of meniscus tears.

Who reads Platelet-derived Growth Factor-coated Decellularized Meniscus Scaffold for Integrative Healing of Meniscus Tears?

Author

Il Lee, Kwang; Olmer, Merissa; Baek, Jihye; D'Lima, Darryl D.; Lotz, Martin K.

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1742-7061)

Published

2018

Language

EN

Field

Engineering (Physical Sciences)