Can I read MACE and VTE across upadacitinib clinical trial programmes in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis on EtoBox?

MACE and VTE across upadacitinib clinical trial programmes in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis by Christina Charles-Schoeman; Ernest Choy; Iain B McInnes; Eduardo Mysler; Peter Nash; Kunihiro Yamaoka; Ralph Lippe; Nasser Khan; Anna K Shmagel; Hannah Palac; Jessica Suboticki; Jeffrey R Curtis is a Medicine article available to read on EtoBox.

What is MACE and VTE across upadacitinib clinical trial programmes in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis about?

## Objectives To provide an integrated analysis of major adverse cardiovascular events (MACEs) and events of venous thromboembolism (VTE) and associated risk factors across rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) phase 2b/3 upadacitinib clinical programmes. ## Methods Data were analysed and summarised from clinical trials of RA, PsA and AS treated with upadacitinib 15 mg once daily (QD) and 30 mg QD (as of 30 June 2021). Data from adalimumab (RA and PsA) and methotrexate (RA) arms were included as comparators. Adjudicated MACEs and VTE events were presented as exposure-adjusted rates per 100 patient-years (E/100 PY). Univariable Cox proportional hazard regression analyses assessed potential associations of risk factors for MACE and VTE. ## Results In total, 4298 patients received upadacitinib 15 mg (RA n=3209, PsA n=907 and AS n=182) and 2125 patients received upadacitinib 30 mg (RA n=1204 and PsA n=921). In patients with RA and PsA, rates of MACE (0.3–0.6 E/100 PY) and VTE (0.2–0.4 E/100 PY) were similar across upadacitinib doses; in patients with AS, no MACEs and one VTE event occurred. Most patients experiencing MACEs or VTE events h

Who reads MACE and VTE across upadacitinib clinical trial programmes in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis?

Author

Christina Charles-Schoeman; Ernest Choy; Iain B McInnes; Eduardo Mysler; Peter Nash; Kunihiro Yamaoka; Ralph Lippe; Nasser Khan; Anna K Shmagel; Hannah Palac; Jessica Suboticki; Jeffrey R Curtis

Publisher

BMJ

Published

2023

Field

Medicine (Health Sciences)