Opening book details…
Can I read Auditory Paired-stimuli Responses Across the Psychosis and Bipolar Spectrum and Their Relationship to Clinical Features on EtoBox?
Auditory Paired-stimuli Responses Across the Psychosis and Bipolar Spectrum and Their Relationship to Clinical Features by David A. Parker; Rebekah L. Trotti; Jennifer E. McDowell; Sarah K. Keedy; Elliot S. Gershon; Elena I. Ivleva; Godfrey D. Pearlson; Matcheri S. Keshavan; Carol A. Tamminga; John A. Sweeney; Brett A. Clementz is a Neuroscience article available to read on EtoBox.
What is Auditory Paired-stimuli Responses Across the Psychosis and Bipolar Spectrum and Their Relationship to Clinical Features about?
## Background: EEG responses during auditory paired-stimuli paradigms are putative biomarkers of psychosis syndromes. The initial iteration of the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP1) showed unique and common patterns of abnormalities across schizophrenia (SZ), schizoaffective disorder (SAD), and bipolar disorder with psychosis (BDP). This study replicates those findings in new and large samples of psychosis cases and extends them to an important comparison group, bipolar disorder without psychosis (BDNP). ## Methods: Paired stimuli responses from 64-sensor EEG recording were compared across psychosis (n = 597; SZ = 225, SAD = 201, BDP = 171), BDNP (n = 66), and healthy (n = 415) subjects from the second iteration of B-SNIP. EEG activity was analyzed in voltage and in the time-frequency domain. Principal component analysis (PCA) over sensors (sPCA) was used to efficiently capture EEG voltage responses to the paired stimuli. Evoked power was calculated via a Morlet wavelet procedure. A frequency PCA divided evoked power data into three frequency bands: Low (4–17 Hz), Beta (18–32 Hz), and Gamma (33–55 Hz). Each time-course (ERP Voltage, Low, Beta, and Ga
Who reads Auditory Paired-stimuli Responses Across the Psychosis and Bipolar Spectrum and Their Relationship to Clinical Features?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- David A. Parker; Rebekah L. Trotti; Jennifer E. McDowell; Sarah K. Keedy; Elliot S. Gershon; Elena I. Ivleva; Godfrey D. Pearlson; Matcheri S. Keshavan; Carol A. Tamminga; John A. Sweeney; Brett A. Clementz
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Neuroscience (Life Sciences)