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An Update on Phosphate Binders for the Treatment of Hyperphosphatemia in Chronic Kidney Disease Patients on Dialysis: a Review of Safety Profiles by Hiroaki Ogata; Akiko Takeshima; Hidetoshi Ito is a Medicine article available to read on EtoBox.

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## Introduction: Hyperphosphatemia is an inevitable complication for patients undergoing dialysis, as is the resulting need for treatment with phosphate binders. currently, various phosphate binders are clinically available. in addition to their phosphate-lowering activity, individual phosphate binders have differing safety profiles and off-target actions. ## Areas covered: This paper reviews the safety of phosphate binders and issues to be resolved. ## Expert opinion: Calcium-based phosphate binders are well tolerated but may increase calcium overload risk. sevelamer reduces serum cholesterol levels and exerts anti-inflammatory effects. compared to sevelamer, bixalomer is associated with fewer gastrointestinal symptoms. aluminum-containing binders, lanthanum carbonate, and sucroferric oxyhydroxide exhibit strong phosphate-lowering activity. although ferric citrate reduces erythropoiesis-stimulating agents and intravenous iron doses, its use requires monitoring of iron metabolic markers to avoid overload. occasionally, combined use of multiple phosphate binders can offer the advantages of each phosphate binder while minimizing their drawbacks; thus, this may be desirable according

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Author

Hiroaki Ogata; Akiko Takeshima; Hidetoshi Ito

Publisher

Informa UK Limited

Published

2022

Language

EN

Field

Medicine (Health Sciences)