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Changes in serum CK-MB mass after coronary artery bypass surgery by Frederick van Lente; Ann M. McHugh; Robert S. Galen is a Medicine article available to read on EtoBox.

What is Changes in serum CK-MB mass after coronary artery bypass surgery about?

We assessed the release of creatine kinase MB as both mass and activity during the postoperative period following cardiac surgery. CK-MB mass was determined by enzyme immunoassay using reagents obtained from Hybritech. CK-MB activity was determined both by agarose electrophoresis and by an immunochemical method. Fifty-five patients who underwent coronary artery bypass surgery and 52 control subjects who had orthopedic surgery were selected for study. Serial serum samples were collected following surgery and total LD, CK, AST, LD-1, CK-MB mass, and CK-MB activity determined. Results were compared to each other and to surgical parameters. All patients exhibited significant CK-MB mass and activity after surgery and peak serum levels were 6-94 Fg/L and 12-84 U/L, respectively. CK-MB mass correlated with CK-MB activity on paired samples (r = 0.94). Total AST and CK activities correlated with CK-MB mass (r = 0.60, and 0.63, respectively). Peak levels of CK-MB mass correlated significantly with peak MB activity (r = 0.88), peak LD-1 (r = 0.62), peak AST (r = 0.71), and time on pump (r = 0.54). Similar correlations were also seen between peak CK-MB activity and these parameters. No relatio

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Author
Frederick van Lente; Ann M. McHugh; Robert S. Galen
Publisher
Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-9120)
Published
1987
Language
EN
Field
Medicine (Health Sciences)

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