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Impella support and acute kidney injury during high‐risk percutaneous coronary intervention: The Global cVAD Renal Protection Study by Michael P. Flaherty; Jeffrey W. Moses; Ralf Westenfeld; Igor Palacios; William W. O'Neill; Theodore L. Schreiber; Michael J. Lim; Amir Kaki; Ioana Ghiu; Roxanna Mehran is a Medicine article available to read on EtoBox.

What is Impella support and acute kidney injury during high‐risk percutaneous coronary intervention: The Global cVAD Renal Protection Study about?

## Abstract ## Background Protection against acute kidney injury (AKI) has been reported with the use of Impella during high‐risk percutaneous coronary intervention (HR‐PCI). We sought to evaluate this finding by determining the occurrence of AKI during Impella‐supported HR‐PCI in patients from the Global cVAD Study and compare this incidence with their calculated AKI risk at baseline. ## Methods and Results In this prospective, multicenter study, we enrolled 314 consecutive patients. We included 223 patients that underwent nonemergent HR‐PCI supported with Impella 2.5 or Impella CP and excluded those requiring hemodialysis prior to HR‐PCI (19) and those with insufficient data (72). The primary outcome was AKI postprocedurally at 48 hr versus the predicted risk of AKI according to Mehran risk score. Logistic regression analysis determined predictors of AKI. Overall, 4.9% (11) of Impella‐supported patients developed AKI (exclusively stage 1) at 48 hr versus a predicted rate of 21.9%, representing a 77.6% lower AKI rate (__p__ < .0001). In this study, no Impella‐supported patients required renal replacement therapy. Estimated glomerular filtration rate (ml/min/1.73 m^2^) alone predic

Who reads Impella support and acute kidney injury during high‐risk percutaneous coronary intervention: The Global cVAD Renal Protection Study?

Author

Michael P. Flaherty; Jeffrey W. Moses; Ralf Westenfeld; Igor Palacios; William W. O'Neill; Theodore L. Schreiber; Michael J. Lim; Amir Kaki; Ioana Ghiu; Roxanna Mehran

Publisher

Wiley

Published

2019

Language

EN

Field

Medicine (Health Sciences)