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Can I read Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants on EtoBox?
Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants by Chia-Chung Hou; Chun-Houh Chen; Ning-Sun Yang; Yi-Ping Chen; Chiu-Ping Lo; Sheng-Yang Wang; Yin-Jing Tien; Pi-Wen Tsai; Lie-Fen Shyur is a Medicine article available to read on EtoBox.
What is Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants about?
Echinacea preparations were the top-selling herbal supplements or medicines in the past decade; however, there is still frequent misidentification or substitution of the Echinacea plant species in the commercial Echinacea products with not well chemically defined compositions in a specific preparation. In this report, a comparative metabolomics study, integrating supercritical fluid extraction, gas chromatography/mass spectrometry and data mining, demonstrates that the three most used medicinal Echinacea species, Echinacea purpurea, E. pallida, and E. angustifolia, can be easily classified by the distribution and relative content of metabolites. A mitogen-induced murine skin inflammation study suggested that alkamides were the active anti-inflammatory components present in Echinacea plants. Mixed alkamides and the major component, dodeca-2E,4E,8Z,10Z(E)-tetraenoic acid isobutylamides, were then isolated from E. purpurea root extracts for further bioactivity elucidation. In macrophages, the alkamides significantly inhibited cyclooxygenase 2 (COX-2) activity and the lipopolysaccharide-induced expression of COX-2, inducible nitric oxide synthase and specific cytokines or chemokines [i
Who reads Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants?
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- Author
- Chia-Chung Hou; Chun-Houh Chen; Ning-Sun Yang; Yi-Ping Chen; Chiu-Ping Lo; Sheng-Yang Wang; Yin-Jing Tien; Pi-Wen Tsai; Lie-Fen Shyur
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0955-2863)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)