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What is Canine Adenovirus Vectors for Lung Gene Transfer about?

This study evaluates the efficacy of canine adenovirus type 2 (CAV-2) vectors for lung-directed gene transfer, highlighting their potential to overcome immune response limitations associated with human adenovirus vectors. CAV-2 demonstrated efficient transduction in both mouse and human pulmonary cells, with reduced inflammatory responses compared to human adenovirus vectors, and the use of a helper-dependent CAV-2 vector extended transgene expression duration to at least three months. The findings suggest

Author

Kanawai

Language

EN