Can I read The Involvement of Kynurenine Pathway in Neurodegenerative Diseases on EtoBox?

The Involvement of Kynurenine Pathway in Neurodegenerative Diseases by Antonio L. Teixeira; Lais B. Martins; Ana L.M. Silveira is a Neuroscience article available to read on EtoBox.

What is The Involvement of Kynurenine Pathway in Neurodegenerative Diseases about?

**__Background__:** A growing body of evidence has shown the involvement of the kynurenine pathway (KP), the primary route of tryptophan (TRP) catabolism, in the pathophysiology of neuropsychiatric disorders. **__Objective__:** The study aims to provide a comprehensive and critical overview of the clinical evidence on the KP involvement in the pathophysiology of Alzheimer’s disease (AD) and Parkinson's disease (PD), discussing therapeutic opportunities. **__Methods__:** We searched for studies investigating KP metabolites in human subjects with AD and/or PD. **__Results__:** Postmortem studies showed altered levels of KP metabolites in the brain of AD and PD patients compared with controls. Cross-sectional studies have reported associations between peripheral levels (serum or plasma) of KP metabolites and cognitive function in these patients, but the results are not always concordant. **__Conclusion__:** Given the emerging evidence of the involvement of KP in the pathophysiology of neuropsychiatric/neurodegenerative diseases and promising results from preclinical pharmacological studies, a better understanding of the KP involvement in AD and PD is warranted. Future longitudinal stu

Who reads The Involvement of Kynurenine Pathway in Neurodegenerative Diseases?

Author

Antonio L. Teixeira; Lais B. Martins; Ana L.M. Silveira

Publisher

Bentham Science Publishers Ltd.

Published

2023

Language

EN

Field

Neuroscience (Life Sciences)