Can I read Pro-inflammatory CXCL-10, TNF-α, IL-1β, and IL-6: biomarkers of SARS-CoV-2 infection on EtoBox?

Pro-inflammatory CXCL-10, TNF-α, IL-1β, and IL-6: biomarkers of SARS-CoV-2 infection by Anuradha S. Tripathy; Siddhesh Vishwakarma; Diptee Trimbake; Yogesh K. Gurav; Varsha A. Potdar; Nitin D. Mokashi; Sudhir D. Patsute; Himanshu Kaushal; Manohar L. Choudhary; Bipin N. Tilekar; Prakash Sarje; Varsha S. Dange; Priya Abraham is a Medicine article available to read on EtoBox.

What is Pro-inflammatory CXCL-10, TNF-α, IL-1β, and IL-6: biomarkers of SARS-CoV-2 infection about?

Currently, the world is witnessing the pandemic of COVID-19, a disease caused by the novel coronavirus SARS-CoV-2. Reported differences in clinical manifestations and outcomes in SARS-CoV-2 infection could be attributed to factors such as virus replication, infiltration of inflammatory cells, and altered cytokine production. Virus-induced aberrant and excessive cytokine production has been linked to the morbidity and mortality of several viral infections. Using a Luminex platform, we investigated plasma cytokine and chemokine levels of 27 analytes from hospitalized asymptomatic (n = 39) and mildly symptomatic (n = 35) SARS-CoV-2-infected patients (in the early phase of infection), recovered individuals (45-60 days postinfection) (n = 40), and uninfected controls (n = 36) from the city of Pune located in the state of Maharashtra in India. Levels of the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α and the chemokine CXCL-10 were significantly higher, while those of the antiviral cytokines IFN-γ and IL-12 p70 were significantly lower in both asymptomatic and mildly symptomatic patients than in controls. Comparison among the patient categories revealed no difference in the levels o

Who reads Pro-inflammatory CXCL-10, TNF-α, IL-1β, and IL-6: biomarkers of SARS-CoV-2 infection?

Author

Anuradha S. Tripathy; Siddhesh Vishwakarma; Diptee Trimbake; Yogesh K. Gurav; Varsha A. Potdar; Nitin D. Mokashi; Sudhir D. Patsute; Himanshu Kaushal; Manohar L. Choudhary; Bipin N. Tilekar; Prakash Sarje; Varsha S. Dange; Priya Abraham

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Life Sciences)