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The HeartMate III: Design and In Vivo Studies of a Maglev Centrifugal Left Ventricular Assist Device by Howard M. Loree II; Kevin Bourque; David B. Gernes; J. Scott Richardson; Victor L. Poirier; Natale Barletta; Andreas Fleischli; Giampiero Foiera; Thomas M. Gempp; Reto Schoeb; Kenneth N. Litwak; Takehide Akimoto; Marina Kameneva; Mary J. Watach; Philip Litwak is a Medicine article available to read on EtoBox.

What is The HeartMate III: Design and In Vivo Studies of a Maglev Centrifugal Left Ventricular Assist Device about?

**Abstract:** A compact implantable centrifugal left ventricular assist device (LVAD) (HeartMate III) featuring a magnetically levitated impeller is under development. The goal of our ongoing work is to demonstrate feasibility, low hemolysis, and low thrombogenicity of the titanium pump in chronic bovine in vivo studies. The LVAD is based on so‐called bearingless motor technology and combines pump rotor, drive, and magnetic bearing functions in a single unit. The impeller is rotated (θ~z~) and levitated with both active (X, Y) and passive (Z, θ~x~, θ~y~) suspension. Six prototype systems have been built featuring an implantable titanium pump (69 mm diameter, 30 mm height) with textured blood contacting surfaces and extracorporeal electronics. The pumps were implanted in 9 calves (≤100 kg at implant) that were anticoagulated with Coumadin (2.5 ≤ INR ≤ 4.0) throughout the studies. Six studies were electively terminated (at 27–61 days), 1 study was terminated after the development of severe pneumonia and lung atelectasis (at 27 days) another study was terminated after cardiac arrest (at 2 days) while a final study is ongoing (at ≈100 days). Mean pump flows ranged from 2 to 7 L/min, ex

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Author

Howard M. Loree II; Kevin Bourque; David B. Gernes; J. Scott Richardson; Victor L. Poirier; Natale Barletta; Andreas Fleischli; Giampiero Foiera; Thomas M. Gempp; Reto Schoeb; Kenneth N. Litwak; Takehide Akimoto; Marina Kameneva; Mary J. Watach; Philip Litwak

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0160-564X)

Published

2001

Language

EN

Field

Medicine (Health Sciences)