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High-resolution 1H NMR spectroscopy of cerebrospinal fluid in spinal diseases by Frank Koschorek; Werner Offermann; Jochen Stelten; Werner E. Braunsdorf; Ulrich Steller; Helmut Gremmel; Dieter Leibfritz is a Medicine article available to read on EtoBox.

What is High-resolution 1H NMR spectroscopy of cerebrospinal fluid in spinal diseases about?

Twenty-nine patients with disk herniations, 7 patients with intraspinal tumors, 4 patients with multiple sclerosis and one patient with infection by borrelia have been studied by CT, myelography and/or MR. To gain information on the metabolism of central nervous system disease (CNS), and thus, to improve diagnosis the cerebrospinal fluid (CSF) was studied in all cases using high-resolution 1H NMR spectroscopy at 360 MHz. Seventeen metabolites could be identified in CSF in addition to the usual clinical chemical parameters. As compared to a control group discrimination of tumors from inflammation was possible by means of different metabolites and/ or metabolite concentration. The CSF in disk herniations differed in the concentration of acetate from the control group. In CSF of tumors, multiple sclerosis and of infection by borrelia distinct differences in the concentrations of putrescine, citrate, valine, ~alanine, acetate, creatinine, glucose, 13-hydroxy-butyric acid, glutamine and creatine have been observed both as compared directly and in comparison to the control group. Thus, high-resolution ~H NMR spectroscopy of CSF gives speedy information on metabolism, since a variety of m

Who reads High-resolution 1H NMR spectroscopy of cerebrospinal fluid in spinal diseases?

Author

Frank Koschorek; Werner Offermann; Jochen Stelten; Werner E. Braunsdorf; Ulrich Steller; Helmut Gremmel; Dieter Leibfritz

Publisher

Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0344-5607)

Published

1993

Language

EN

Field

Medicine (Health Sciences)