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Augmented Degradation of Factors VIII and IX in the Intermittent Movement State by Haim Cohen; Anat Keren-Politansky; Yonatan Crispel; Chen Yanovich; Keren Asayag; Yona Nadir is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Augmented Degradation of Factors VIII and IX in the Intermittent Movement State about?

The most common clinical presentation of hemophilia A and hemophilia B is bleeding in large joints and striated muscles. It is unclear why bleeding has a predilection to affect joints and muscles. As muscles and joints are involved in intermittent movement, we explored whether this phenomenon could be associated with an impact on factor VIII and IX levels. Purified proteins and a mouse model were assessed using coagulation assays, Western blot analysis and immuno-staining. Movement caused an increase in thrombin activity and a decrease in factor VIII and factor IX activity. The decrease in factor VIII activity was more significant in the presence of thrombin and during movement. Under movement condition, sodium ions appeared to enhance the activity of thrombin that resulted in decreased factor VIII activity. Unlike factor VIII, the reduction in factor IX levels in the movement condition was thrombin-independent. High factor VIII levels were found to protect factor IX from degradation and vice versa. In mice that were in movement, factor VIII and IX levels decreased in the microcirculation of the muscle tissue compared with other tissues and to the muscle tissue at rest. Movement ha

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Author

Haim Cohen; Anat Keren-Politansky; Yonatan Crispel; Chen Yanovich; Keren Asayag; Yona Nadir

Publisher

MDPI AG

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)