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Calpain 10 gene and laryngeal cancer: A survival analysis by Ramón Moreno‐Luna; Antonio Abrante; Francisco Esteban; Miguel Angel González‐Moles; Miguel Delgado‐Rodríguez; María Eugenia Sáez; Antonio González‐Pérez; Reposo Ramírez‐Lorca; Luis Miguel Real; Agustín Ruiz is a Medicine article available to read on EtoBox.
What is Calpain 10 gene and laryngeal cancer: A survival analysis about?
## Abstract ## Background Laryngeal carcinoma is a common upper respiratory tract cancer with different environmental and genetic factors involved in its development. Calpains are Ca2+‐dependent cysteine proteases that modulate cellular function. A novel association between calpain 10 (__CAPN10__) haplotypes and laryngeal cancer has been found recently. Therefore, the goal of this study was to analyze the contribution of __CAPN10__ alleles to laryngeal cancer survival. ## Methods Patients were recruited from southern Spain. Genotypes were determined using pyrosequencing technology. We analyzed __CAPN10__ UCSNP‐44, UCSNP‐43, UCSNP‐19, and UCSNP‐63 allelic distributions in 199 patients with unrelated laryngeal cancer. Survival curves were calculated from the date of the intervention to the date of death. Multivariate analyses were done using the Cox proportional risk model. ## Results UCSNP‐19, UCSNP‐43, and UCSNP‐44 were unrelated to survival in both univariate and multivariate analyses. However, for UCSNP‐63 genotype 12 a significant relationship was observed in multivariate analysis (hazard ratio [HR] = 2.73; 95% confidence interval [CI], 1.21–6.20). ## Conclusion __CAPN10__ UCSNP
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- Author
- Ramón Moreno‐Luna; Antonio Abrante; Francisco Esteban; Miguel Angel González‐Moles; Miguel Delgado‐Rodríguez; María Eugenia Sáez; Antonio González‐Pérez; Reposo Ramírez‐Lorca; Luis Miguel Real; Agustín Ruiz
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1043-3074)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)