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Clinical utility of circulating tumor DNA as a response and follow-up marker in cancer therapy by Pieter A. Boonstra; Thijs T. Wind; Michel van Kruchten; Ed Schuuring; Geke A. P. Hospers; Anthonie J. van der Wekken; Derk-Jan de Groot; Carolien P. Schröder; Rudolf S. N. Fehrmann; Anna K. L. Reyners is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Clinical utility of circulating tumor DNA as a response and follow-up marker in cancer therapy about?

## Abstract Response evaluation for cancer treatment consists primarily of clinical and radiological assessments. In addition, a limited number of serum biomarkers that assess treatment response are available for a small subset of malignancies. Through recent technological innovations, new methods for measuring tumor burden and treatment response are becoming available. By utilization of highly sensitive techniques, tumor-specific mutations in circulating DNA can be detected and circulating tumor DNA (ctDNA) can be quantified. These so-called liquid biopsies provide both molecular information about the genomic composition of the tumor and opportunities to evaluate tumor response during therapy. Quantification of tumor-specific mutations in plasma correlates well with tumor burden. Moreover, with liquid biopsies, it is also possible to detect mutations causing secondary resistance during treatment. This review focuses on the clinical utility of ctDNA as a response and follow-up marker in patients with non-small cell lung cancer, melanoma, colorectal cancer, and breast cancer. Relevant studies were retrieved from a literature search using PubMed database. An overview of the available

Who reads Clinical utility of circulating tumor DNA as a response and follow-up marker in cancer therapy?

Author

Pieter A. Boonstra; Thijs T. Wind; Michel van Kruchten; Ed Schuuring; Geke A. P. Hospers; Anthonie J. van der Wekken; Derk-Jan de Groot; Carolien P. Schröder; Rudolf S. N. Fehrmann; Anna K. L. Reyners

Publisher

Springer; Springer-Verlag; Kluwer Academic Publishers; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0167-7659)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)