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Can I read Pleuromutilin derivatives having a purine ring. Part 2: Influence of the central spacer on the antibacterial activity against Gram-positive pathogens on EtoBox?
Pleuromutilin derivatives having a purine ring. Part 2: Influence of the central spacer on the antibacterial activity against Gram-positive pathogens by Yoshimi Hirokawa; Hironori Kinoshita; Tomoyuki Tanaka; Takanori Nakamura; Koichi Fujimoto; Shigeki Kashimoto; Tsuyoshi Kojima; Shiro Kato is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Pleuromutilin derivatives having a purine ring. Part 2: Influence of the central spacer on the antibacterial activity against Gram-positive pathogens about?
Structural modification of the 4-piperidinethio moiety, as a spacer of the first pleuromutilin analogues 2A and 2B having a purine ring, led to discovery of the novel pleuromutilin derivatives 14B and 17B. These compounds with good solubility in water showed promising in vitro antibacterial activity against various Gram-positive bacteria including MRSA, PRSP, and VRE and have potent in vivo efficacy.
Who reads Pleuromutilin derivatives having a purine ring. Part 2: Influence of the central spacer on the antibacterial activity against Gram-positive pathogens?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yoshimi Hirokawa; Hironori Kinoshita; Tomoyuki Tanaka; Takanori Nakamura; Koichi Fujimoto; Shigeki Kashimoto; Tsuyoshi Kojima; Shiro Kato
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)