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CCL18 as an indicator of pulmonary fibrotic activity in idiopathic interstitial pneumonias and systemic sclerosis by Antje Prasse; Dmitri V. Pechkovsky; Galen B. Toews; Markus Schäfer; Stephan Eggeling; Corinna Ludwig; Martin Germann; Florian Kollert; Gernot Zissel; Joachim Müller-Quernheim is a Medicine article available to read on EtoBox.
What is CCL18 as an indicator of pulmonary fibrotic activity in idiopathic interstitial pneumonias and systemic sclerosis about?
## Abstract ## Objective In diffuse parenchymal lung diseases, the evolution of pulmonary fibrosis is often devastating and may result in death. In this study the role of CCL18 as a biomarker of disease activity in idiopathic interstitial pneumonias (IIPs) and systemic sclerosis (SSc) with lung involvement was evaluated. ## Methods CCL18 was assessed in supernatants of cultured bronchoalveolar lavage (BAL) cells as well as BAL fluid and serum samples from 43 patients with IIPs, 12 patients with SSc, and 23 healthy control subjects. Concentrations of CCL18 were measured by enzyme‐linked immunosorbent assay, and expression of CCL18 was assessed by flow cytometry. ## Results CCL18 concentrations were statistically significantly increased in all patients with fibrotic lung diseases. Spontaneous CCL18 production by BAL cells was negatively correlated with total lung capacity and the diffusion capacity for carbon monoxide, whereas there was a positive correlation of CCL18 concentrations with BAL neutrophil and eosinophil cell counts. Flow cytometry revealed an increase in the percentage of CCL18‐positive alveolar macrophages and an increase in the CCL18 fluorescence intensity per cell in
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- Author
- Antje Prasse; Dmitri V. Pechkovsky; Galen B. Toews; Markus Schäfer; Stephan Eggeling; Corinna Ludwig; Martin Germann; Florian Kollert; Gernot Zissel; Joachim Müller-Quernheim
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)