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Specific immune responses after booster immunization with tetanus toxoid in man: Study of kinetics, family segregation, and linkage to HLA of in vitro lymphocyte proliferative responses and serum-antibody responses by J. J. Ballet; C. Rabian-Herzog; M. Lathrop; J. -F. Bourge; M. Agrapart; J. Drouet; J. -M. Lalouel; J. Dausset is a Immunology and Microbiology article available to read on EtoBox.

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Kinetics and family transmission of antigen-specific in vitro cellmediated responses were investigated in 68, and serum-antibody responses to tetanus toxoid (TT) in 73 individuals from a total of 12 families. Proliferative responses to highly purified TT monomer were studied in 6-to 7-day lymphocyte cultures. The effect of booster immunization was detectable 7 (DT) and 30 (D30), but not 120 days (D120) later. The sex of donors was not found to have any influence. A significant influence of the time interval since the last immunization was found for the responses at D 7 and D30. Data were correspondingly adjusted for segregation and linkage analyses. Several transmission hypotheses for the data obtained at D 7 and D30 were evaluated by likelihood ratio tests. Observations at D30 were compatible with the hypothesis of a control by a dominant genetic determinant for high responses closely linked to the major histocompatibility complex region. No such evidence could be found for D 7. After booster immunization, mean antibody levels determined on D7, D30 (peak of response), and D 120 were found to be higher than those prior to immunization (Do). The sex of the donors was found to have n

Who reads Specific immune responses after booster immunization with tetanus toxoid in man: Study of kinetics, family segregation, and linkage to HLA of in vitro lymphocyte proliferative responses and serum-antibody responses?

Author

J. J. Ballet; C. Rabian-Herzog; M. Lathrop; J. -F. Bourge; M. Agrapart; J. Drouet; J. -M. Lalouel; J. Dausset

Publisher

Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0093-7711)

Published

1983

Language

EN

Field

Immunology and Microbiology (Life Sciences)