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The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators by Yingcai Wang; Xianyun Jiao; Frank Kayser; Jiwen Liu; Zhongyu Wang; Malgorzata Wanska; Joanne Greenberg; Jennifer Weiszmann; Hongfei Ge; Hui Tian; Simon Wong; Ralf Schwandner; Taeweon Lee; Yang Li is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators about?
Free fatty acid receptor 2 (FFA2) is a G-protein coupled receptor for which only short-chain fatty acids (SCFAs) have been reported as endogenous ligands. We describe the discovery and optimization of phenylacetamides as allosteric agonists of FFA2. These novel ligands can suppress adipocyte lipolysis in vitro and reduce plasma FFA levels in vivo, suggesting that these allosteric modulators can serve as pharmacological tools for exploring the potential function of FFA2 in various disease conditions.
Who reads The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yingcai Wang; Xianyun Jiao; Frank Kayser; Jiwen Liu; Zhongyu Wang; Malgorzata Wanska; Joanne Greenberg; Jennifer Weiszmann; Hongfei Ge; Hui Tian; Simon Wong; Ralf Schwandner; Taeweon Lee; Yang Li
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)