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Can I read The Ethics of Gene Therapy for Hemophilia: a Narrative Review on EtoBox?
The Ethics of Gene Therapy for Hemophilia: a Narrative Review by Lieke Baas; Rieke van der Graaf; Evelien S. van Hoorn; Annelien L. Bredenoord; Karina Meijer is a Medicine article available to read on EtoBox.
What is The Ethics of Gene Therapy for Hemophilia: a Narrative Review about?
Gene therapy is expected to become a promising treatment, and potentially even a cure, for hemophilia. After several years of research, the first gene therapy product has been granted conditional market authorization by the European Union in August 2022. The recent progress in the field also has implications on the ethical aspects of hemophilia gene therapy. Reviews conducted in the 2000s mainly identified questions on the ethics of conducting early-phase clinical trials. However, since then, the knowledge on safety and efficacy has improved, and the field has moved toward clinical application, a phase that has its own ethical aspects. Therefore, we conducted a narrative review to take stock of the ethical aspects of hemophilia gene therapy. Based on our analysis of the literature, we identified 3 ethical themes. The theme Living up to expectations describes the existing hopes for gene therapy and the unlikelihood of the currently approved product becoming a permanent cure. In the theme Psychosocial impacts, we discuss the fear that gene therapy will impact the identity of people with hemophilia and their need for psychosocial support. The theme Costs and access discusses the expec
Who reads The Ethics of Gene Therapy for Hemophilia: a Narrative Review?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Lieke Baas; Rieke van der Graaf; Evelien S. van Hoorn; Annelien L. Bredenoord; Karina Meijer
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)