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Can I read Up-Regulation of Connexin45 in Heart Failure on EtoBox?
Up-Regulation of Connexin45 in Heart Failure by KATHRYN A. YAMADA; JOSEPH G. ROGERS; RUNE SUNDSET; THOMAS H. STEINBERG; JEFFREY E. SAFFITZ is a Medicine article available to read on EtoBox.
What is Up-Regulation of Connexin45 in Heart Failure about?
__Introduction:__ Heart failure is associated with reduced expression of the major gap junction protein connexin43 (Cx43), which may contribute to arrhythmias and sudden cardiac death in this patient population. Other cardiac connexins may be altered as well. Because connexin45 (Cx45) has been shown to colocalize with Cx43, we determined whether the number, size, or distribution of Cx45 gap junctions is altered in the failing heart. __Methods and Results:__ Cx45 expression levels were measured by immunoblotting and quantitative immunostaining in failing and control human left ventricles. Total Cx45 protein was significantly (P = 0.021) up‐regulated 1.8‐fold in failing hearts. Cx45 immunohistochemical signal was increased by 80% (P = 0.005) due to a 3.5‐fold increase in the number of gap junctions containing Cx45. Cx45 mRNA was not altered in failing hearts, suggesting reduced degradation of Cx45 protein in the failing heart. Cx43 signal, on the other hand, was reduced by 49% in failing hearts. Double‐label experiments demonstrated colocalization of Cx45 and Cx43 in the same gap junctions. __Conclusion:__ Cx45 is markedly enhanced in the failing heart. Up‐regulation of Cx45 in conju
Who reads Up-Regulation of Connexin45 in Heart Failure?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- KATHRYN A. YAMADA; JOSEPH G. ROGERS; RUNE SUNDSET; THOMAS H. STEINBERG; JEFFREY E. SAFFITZ
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Futura Publishing Company, Inc; Blackwell Publishing Inc.; Wiley (ISSN 1540-8167)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)