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Immune Response Following Miltefosine Therapy in a Patient with Post-kala-azar Dermal Leishmaniasis by Nasim Akhtar Ansari; V. Ramesh; Poonam Salotra is a Medicine article available to read on EtoBox.

What is Immune Response Following Miltefosine Therapy in a Patient with Post-kala-azar Dermal Leishmaniasis about?

We report a case of post-kala-azar dermal leishmaniasis in which real-time PCR was exploited to measure changes in cytokine transcripts in lesion tissue before and after oral miltefosine treatment. Unlike antimonial therapy elevated levels of IFN␥ transcripts were noted, whereas TNF␣, IL-10 and transforming growth factor-␤ declined similar to that observed after therapy with antimonials. A significant increase in IFN␥ and CD40 levels seen after miltefosine therapy could enhance parasite clearance. The patient remained normal after 18 months of follow-up.

Who reads Immune Response Following Miltefosine Therapy in a Patient with Post-kala-azar Dermal Leishmaniasis?

Author

Nasim Akhtar Ansari; V. Ramesh; Poonam Salotra

Publisher

Elsevier Science; Oxford University Press; Oxford University Press (OUP); ScienceOpen (ISSN 0035-9203)

Published

2008

Language

EN

Field

Medicine (Health Sciences)