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Molecularly Defined Circuits for Cardiovascular and Cardiopulmonary Control by Avin Veerakumar; Andrea R. Yung; Yin Liu; Mark A. Krasnow is a Physics and Astronomy article available to read on EtoBox.

What is Molecularly Defined Circuits for Cardiovascular and Cardiopulmonary Control about?

The sympathetic and parasympathetic nervous systems regulate the activities of internal organs, but the molecular and functional diversity of their constituent neurons and circuits remains largely unknown. Here we use retrograde neuronal tracing, single-cell RNA sequencing, optogenetics and physiological experiments to dissect the cardiac parasympathetic control circuit in mice. We show that cardiac-innervating neurons in the brainstem nucleus ambiguus (Amb) are comprised of two molecularly, anatomically and functionally distinct subtypes. The first, which we call ambiguus cardiovascular (ACV) neurons (approximately 35 neurons per Amb), define the classical cardiac parasympathetic circuit. They selectively innervate a subset of cardiac parasympathetic ganglion neurons and mediate the baroreceptor reflex, slowing heart rate and atrioventricular node conduction in response to increased blood pressure. The other, ambiguus cardiopulmonary (ACP) neurons (approximately 15 neurons per Amb) innervate cardiac ganglion neurons intermingled with and functionally indistinguishable from those innervated by ACV neurons. ACP neurons also innervate most or all lung parasympathetic ganglion neurons

Who reads Molecularly Defined Circuits for Cardiovascular and Cardiopulmonary Control?

Author

Avin Veerakumar; Andrea R. Yung; Yin Liu; Mark A. Krasnow

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Physics and Astronomy (Physical Sciences)