About this Medicine article

Hypoglycemia in Infants with Hypoxic-Ischemic Encephalopathy Is Associated with Additional Brain Injury and Worse Neurodevelopmental Outcome by Corline E.J. Parmentier; Linda S. de Vries; Niek E. van der Aa; Maria J.C. Eijsermans; Johanneke C. Harteman; Maarten H. Lequin; Henriette F.N. Swanenburg de Veye; Corine Koopman-Esseboom; Floris Groenendaal is a Medicine article available to read on EtoBox.

## Objective: To determine the incidence of hypoglycemia among infants with hypoxic-ischemic encephalopathy (hie) who received therapeutic hypothermia, and to assess whether infants with hypoglycemia had more brain injury on magnetic resonance imaging (mri) or differences in neurodevelopmental outcome. ## Study design: Single-center, retrospective cohort study including infants cooled for hie. hypoglycemia (blood glucose <36.0 mg/dl <2 hours and <46.8 mg/dl ≥2 hours after birth) was analyzed in the period before brain mri. brain injury was graded using a validated score. motor and neurocognitive outcomes were assessed at 2 years for all survivors, and 5.5 years for a subset who had reached this age. ## Results: Of 223 infants analyzed, 79 (35.4%) had hypoglycemia. mri was performed in 187 infants. infants with hypoglycemia (n = 65) had higher brain injury scores (p = .018). after adjustment for hie severity, hypoglycemia remained associated with higher injury scores (3.6 points higher; 95% ci, 0.8-6.4). hyperglycemia did not affect mri scores. in survivors at 2 years (n = 154) and 5.5 years (n = 102), a univariable analysis showed lower 2-year motor scores and lower motor and cogni

Author

Corline E.J. Parmentier; Linda S. de Vries; Niek E. van der Aa; Maria J.C. Eijsermans; Johanneke C. Harteman; Maarten H. Lequin; Henriette F.N. Swanenburg de Veye; Corine Koopman-Esseboom; Floris Groenendaal

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)