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Activity of Decitabine as Maintenance Therapy in Core Binding Factor Acute Myeloid Leukemia by Jayastu Senapati; Mahran Shoukier; Guillermo Garcia‐Manero; Xuemei Wang; Keyur Patel; Tapan Kadia; Farhad Ravandi; Naveen Pemmaraju; Maro Ohanian; Naval Daver; Courtney DiNardo; Yesid Alvarado; Jeffrey Aldrich; Gautam Borthakur is a Medicine article available to read on EtoBox.

What is Activity of Decitabine as Maintenance Therapy in Core Binding Factor Acute Myeloid Leukemia about?

## Abstract ## Background Posttherapy measurable residual disease (MRD) positivity in core binding factor acute myeloid leukemia (CBF‐AML) is associated with shorter relapse‐free survival (RFS). Elimination of MRD measured via quantitative reverse transcription polymerase chain reaction (qRTPCR) for disease specific transcripts can potentially lead to better outcomes in CBF‐AML. ## Methods We prospectively monitored the MRD using qRTPCR and flow cytometry on bone marrow samples in patients with newly diagnosed CBF‐AML who received decitabine (DAC) maintenance therapy after fludarabine/cytarabine/G‐CSF (FLAG)‐based induction/consolidation regimen. Negative qRTPCR (CMR) was defined as fusion transcript <0.01%. ## Results Thirty‐one patients with CBF‐AML including 14 with t(8;21) and 17 with inv(16) received parenteral DAC as maintenance therapy. Fifteen patients (48.3%) had completed FLAG‐based induction/consolidation but with positive MRD (0.35%, range = 0.01%–0.91%) (Group 1). Sixteen patients (51.7%) could not complete recommended consolidations with FLAG‐based regimen (due to older age or complications) and were switched to DAC maintenance (Group 2). In Group 2, eight patients (5

Who reads Activity of Decitabine as Maintenance Therapy in Core Binding Factor Acute Myeloid Leukemia?

Author

Jayastu Senapati; Mahran Shoukier; Guillermo Garcia‐Manero; Xuemei Wang; Keyur Patel; Tapan Kadia; Farhad Ravandi; Naveen Pemmaraju; Maro Ohanian; Naval Daver; Courtney DiNardo; Yesid Alvarado; Jeffrey Aldrich; Gautam Borthakur

Publisher

Wiley

Published

2022

Language

EN

Field

Medicine (Health Sciences)