Opening book details…
Can I read Spread of measles virus through axonal pathways into limbic structures in the brain of TAP1 -/- mice on EtoBox?
Spread of measles virus through axonal pathways into limbic structures in the brain of TAP1 -/- mice by Urbanska, Ewa M.; Chambers, Benedict J.; Ljunggren, Hans-Gustaf; Norrby, Erling; Kristensson, Krister is a Medicine article available to read on EtoBox.
What is Spread of measles virus through axonal pathways into limbic structures in the brain of TAP1 -/- mice about?
The spread of measles virus into the brain was studied exploiting the olfactory pathway, which represents an important route of neuroinvasion by viruses. The virus was injected into the main olfactory bulb of wild-type mice and mice with disrupted TAP1 gene (TAP refers to the Transporter associated with Antigen Presentation), which codes for products essential for the cell-mediated immune response. Virus invasion was monitored for 4 weeks by immunohistochemistry. The distribution of measles virus was found to be restricted to brain areas connected with the olfactory bulbs. However, in the wild-type mice there was a marked infiltration of lymphocytes in the infected brain structures, and the virus did not pass beyond the piriform cortex. In the TAP1 -/- mice the virus spread more extensively along olfactory projections into the limbic system and monoaminergic brainstem neurons. Infected mice of both types developed seizures, which may have been focally evoked from the piriform cortex. This study provides evidence that measles virus can spread through axonal pathways in the brain. The findings obtained in the gene-manipulated mice point out that a compromised immune state of the host
Who reads Spread of measles virus through axonal pathways into limbic structures in the brain of TAP1 -/- mice?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Urbanska, Ewa M.; Chambers, Benedict J.; Ljunggren, Hans-Gustaf; Norrby, Erling; Kristensson, Krister
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)