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Association Between Pyramidal Neurone Spiking in the Medial Prefrontal Cortex and the Sedative Potency of Volatile Anaesthetics in Mice by Yu Leng & Yaoxin Yang & Qian Li & Yujie Wu & Han Huang & Peng Liang & Donghang Zhang & Cheng Zhou & Hugh C. Hemmings Jr. is a nonfiction available to read on EtoBox.
What is Association Between Pyramidal Neurone Spiking in the Medial Prefrontal Cortex and the Sedative Potency of Volatile Anaesthetics in Mice about?
British Journal of Anaesthesia, Corrected proof. doi:10.1016/j.bja.2025.07.046AbstractBackground: The mechanisms underlying volatile anaesthetic-induced unconsciousness remain unclear. Glutamatergicpyramidal neurones and fast-spiking interneurones in cerebral cortex circuits play distinct roles in cortical networkdynamics under volatile anaesthesia. We investigated the roles of medial prefrontal cortex (mPFC) pyramidal and fastspiking interneurones in volatile anaesthetic-induced hypnosis.Methods: The electrophysiological properties of pyramidal and fast-spiking parvalbumin (PV+) neurones were exploredby in vivo multichannel recordings and in vitro patch-clamp electrophysiological recordings. Chemogenetic manipulationwas used to test the role of pyramidal neurones in the mPFC in volatile anaesthetic-induced unconsciousness. Nav1.1knockdown in PV+ neurones was used to regulate activities of pyramidal neurones by PV+-dependent disinhibition andto investigate the role of pyramidal neurone activation in volatile anaesthetic-induced unconsciousness.Results: Regular-spiking pyramidal neurones and fast-spiking PV+ neurones in the mPFC were identified with distinctspiking properties. Sevo
Who reads Association Between Pyramidal Neurone Spiking in the Medial Prefrontal Cortex and the Sedative Potency of Volatile Anaesthetics in Mice?
It is typically read by self-directed learners exploring a subject in depth.
Common subject areas: history, science, philosophy, social sciences.
- Author
- Yu Leng & Yaoxin Yang & Qian Li & Yujie Wu & Han Huang & Peng Liang & Donghang Zhang & Cheng Zhou & Hugh C. Hemmings Jr.
- Publisher
- x
- Published
- 2025
- Language
- EN
- Category
- nonfiction
- Subjects
- Medical, Others, Medicine
More by Yu Leng & Yaoxin Yang & Qian Li & Yujie Wu & Han Huang & Peng Liang & Donghang Zhang & Cheng Zhou & Hugh C. Hemmings Jr.
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