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Characterization of castration-induced cell death in the rat prostate by immunohistochemical localization of cathepsin D by Julia A. Sensibar; Xianxi Liu; Barbara Patai; Brad Alger; Dr. Chung Lee is a Medicine article available to read on EtoBox.

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## Abstract Activities of cathepsin D (EC 3.4.23.5) were determined in three lobes of the prostate during their involution by both biochemical and immunohistochemical procedures. The activity of cathepsin D in noncastrated rats was 0.9 ± 0.2 (mean ± SE) 5.7 ± 0.6, and 13.1 ± 0.8 units/mg protein for the ventral, lateral, dorsal lobes, respectively. Following castration, there was a significant increase in enzymatic activity in all three lobes within 2–3 days. In the ventral lobe, the activity peaked in 5 days to 6.2 ± 0.9 units/mg protein and declined slightly thereafter. In the lateral and dorsal lobes, the activity remained elevated (14–20 units/mg protein) throughout the postcastration period studied. Immunohistochemical staining of cathepsin D was localized in the cytoplasm of prostatic epithelial cells as fine discrete lysosomal granules. These granules were larger and more abundant in the dorsal and lateral lobes than in the ventral lobe and were not detected in prostatic stromal cells and seldom in the luminal fluid. Castration resulted in an immediate increase in the size and number of these granules in the epithelial cells, followed by a sudden further increase in cathepsi

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Author

Julia A. Sensibar; Xianxi Liu; Barbara Patai; Brad Alger; Dr. Chung Lee

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)

Published

1990

Language

EN

ISBN

9782990160315

Field

Medicine (Health Sciences)