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Oral step-down therapy is comparable to intravenous therapy for Staphylococcus aureus osteomyelitis by Naval G. Daver; Samuel A. Shelburne; Robert L. Atmar; Thomas P. Giordano; Charles E. Stager; Charles A. Reitman; A. Clinton White Jr. is a Medicine article available to read on EtoBox.
What is Oral step-down therapy is comparable to intravenous therapy for Staphylococcus aureus osteomyelitis about?
Background: We hypothesized that regimens with an early switch to oral antibiotics are as effective as prolonged parenteral regimens for staphylococcal osteomyelitis. Methods: We retrospectively reviewed records of adult patients with osteomyelitis caused by Staphylococcus aureus as determined by sterile site cultures, who had at least 6 months of follow-up post-therapy. The population was divided into two treatment groups: (1) an intravenous group (IV) that received 4 weeks of parenteral therapy, and (2) a switch group that received < 4 weeks of intravenous followed by oral therapy. Results: A total of 72 patients (36 in each group) were identified with groups evenly matched for demographic and clinical characteristics. The overall apparent cure rate was 74%; 69% for the IV group and 78% for the switch group (P Z 0.59). Apparent cure rates were similar regardless of duration of intravenous therapy: 83% < 2 weeks, 72% 2e4 weeks, 75% 4e6 weeks and 66% 6 weeks (P Z 0.68). Among the 39 patients who received rifampin-based combinations, those treated simultaneously with vancomycin and rifampin did significantly worse than those who received other rifampin combinations (P < 0.02). Overa
Who reads Oral step-down therapy is comparable to intravenous therapy for Staphylococcus aureus osteomyelitis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Naval G. Daver; Samuel A. Shelburne; Robert L. Atmar; Thomas P. Giordano; Charles E. Stager; Charles A. Reitman; A. Clinton White Jr.
- Publisher
- Elsevier Science; Elsevier ; W. B. Saunders Co., Ltd.; Elsevier BV (ISSN 0163-4453)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)