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Surface Modification of Commercial Intraocular Lens by Zwitterionic and Antibiotic-loaded Coating for Preventing Postoperative Endophthalmitis by Kaijun Li; Ling Yu; Li Ma; Jiali Xia; Jinyu Peng; Pan Hu; Gongyan Liu; Jian Ye is a Materials Science article available to read on EtoBox.

What is Surface Modification of Commercial Intraocular Lens by Zwitterionic and Antibiotic-loaded Coating for Preventing Postoperative Endophthalmitis about?

After cataract surgery, to prevent possible postoperative endophthalmitis (POE) caused by attached pathogenic bacteria onto the surface of implanted intraocular lens (IOL), various antibiotic-loaded IOLs have been proposed and widely studied to inhibit bacterial infection. However, most of these developed antibiotic-loaded IOLs still suffer from shortcomings such as insufficient drug loading, short release time, poor biocompatibility, and risk of secondary infection. Herein, we propose a zwitterionic and high-drug loading coating for surface modification of commercial hydrophobic IOL with both antifouling and antibacterial properties to effectively prevent POE. In this strategy, zwitterionic poly(carboxylbetaine-co-dopamine methacrylamide) copolymers (pCBDA) and dopamine (DA) were first robustly co-deposited onto IOL surface via facile mussel-inspired chemistry, resulting in a hydrophilic coating (defined as PCB) without sacrificing the high light transmittance of the native IOL. Subsequently, amikacin (AMK), an amine-rich antibiotic was reversibly conjugated onto the coating through the acid-sensitive Schiff base bonds formed by the reaction between amino and catechol groups, with

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Author

Kaijun Li; Ling Yu; Li Ma; Jiali Xia; Jinyu Peng; Pan Hu; Gongyan Liu; Jian Ye

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Materials Science (Physical Sciences)