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Mimicking Human Bipolar Ion Dysregulation Models Mania in Rats by Laura Herman; Tyler Hougland; Rif S. El-Mallakh is a Neuroscience article available to read on EtoBox.
What is Mimicking Human Bipolar Ion Dysregulation Models Mania in Rats about?
Psychiatric diseases in general, and bipolar illness in particular, are difficult to model in animals since the subjective nature of the core symptoms appears to preclude objective observation of behavioral changes. An adequate animal model of a psychiatric condition must fulfill three core criteria: share pathophysiological characteristics of the human condition (face validity), have similar behavioral manifestations as the human disease (construct validity), and improve with medications that improve the symptoms seen in afflicted humans (predictive validity). The ouabain model for bipolar illness mimics a widely reproduced biologic abnormality in mania: reduced sodium pump activity. An intracerebroventricular (ICV) administration of 5microL 10(-3)M ouabain induces motoric hyperactivity preventable by lithium, carbamazepine, and haloperidol. ICV ouabain may also produce environmentally dependent hypoactivity. The model, however, has not yet been examined for other potential manic behavior in rats such as reduced need for sleep, increased sexual activity, or increased irritability. While additional characterization of the model is required, the ouabain model for bipolar illness is
Who reads Mimicking Human Bipolar Ion Dysregulation Models Mania in Rats?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Laura Herman; Tyler Hougland; Rif S. El-Mallakh
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0149-7634)
- Published
- 2007
- Language
- EN
- Field
- Neuroscience (Life Sciences)