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Can I read Inducers, Attractors and Modulators of CD4^+^ Treg Cells in Non-Small-Cell Lung Cancer on EtoBox?
Inducers, Attractors and Modulators of CD4^+^ Treg Cells in Non-Small-Cell Lung Cancer by Xie, Mengxiao; Wei, Jia; Xu, Jian is a Immunology and Microbiology article available to read on EtoBox.
What is Inducers, Attractors and Modulators of CD4^+^ Treg Cells in Non-Small-Cell Lung Cancer about?
Lung cancer is the leading cause of cancer-associated deaths worldwide, with non-small cell-lung cancer (NSCLC) accounting for approximately 80% of cases. Immune escape has been demonstrated to play a key role in the initiation and progression of NSCLC, although the underlying mechanisms are diverse and their puzzling nature is far from being understood. As a critical participant in immune escape, the CD4^+^ T cell subset of regulatory T (Treg) cells, with their immunosuppressive functions, has been implicated in the occurrence of many types of cancers. Additionally, therapies based on Treg blockade have benefited a portion of cancer patients, including those with NSCLC. Accumulating literature has noted high Treg infiltration in NSCLC tumor tissues, bone marrow, lymph nodes and/or blood; moreover, the tumor milieu is involved in regulating the proliferation, differentiation, recruitment and suppressive functions of Treg cells. Multifarious mechanisms by which CD4^+^ Treg cells are generated, attracted and modulated in the NSCLC milieu will be discussed in this review.
Who reads Inducers, Attractors and Modulators of CD4^+^ Treg Cells in Non-Small-Cell Lung Cancer?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Xie, Mengxiao; Wei, Jia; Xu, Jian
- Publisher
- Frontiers; Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2010- (ISSN 1664-3224)
- Published
- 2020
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)