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Effects of inflammatory cytokines IL‐1β, IL‐6, and TNFα on the intracellular localization of retinoid receptors in Schwann cells by Jörg Mey; Kirsten Schrage; Inga Wessels; Ilona Vollpracht‐Crijns is a Neuroscience article available to read on EtoBox.

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## Abstract It was investigated whether retinoic acid (RA) and the proinflammatory cytokines IL‐1β, IL‐6, and TNFα influence the intracellular distribution of retinoic acid receptors (RAR) and retinoid X receptors (RXR) in Schwann cells. This question arose because nuclear translocation of RARα, RXRα, and RXRβ was observed after nerve injury, and because mutual interactions exist between the signal transduction pathways of RA and proinflammatory cytokines. Schwann cell primary cultures from the rat sciatic nerve were incubated with IL‐1β, IL‐6, and TNFα, with all‐__trans__ RA and with a combination of IL‐1β and RA. After incubation periods ranging from 5 min to 5 h, the intracellular distributions of RARα, RARβ, RXRα, and RXRβ were analyzed. All three cytokines caused a shift of RARα from the cytosolic compartments into the cell nuclei. This was also observed with RA, and combining RA with IL‐1β produced an additive effect. IL‐1β and IL‐6 also affected the distribution of RARβ, although immunoreactivity of this receptor always remained stronger in the cytosol. No effect of the cytokines on RXRα or RXRβ was observed, whereas RA treatment caused a stronger nuclear signal of both rece

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Author

Jörg Mey; Kirsten Schrage; Inga Wessels; Ilona Vollpracht‐Crijns

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0894-1491)

Published

2006

Language

EN

Field

Neuroscience (Life Sciences)