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Electrolyte Imbalance in Anti-LGI1 Encephalitis: It Is Not All in Your Head by Avi Gadoth; Michal Nisnboym; Yifat Alcalay; Asia Zubkov; Idit Schwartz; Doron Schwartz; Marana Abboud; Tamar Rubinek; Ofer Yossepowitch; Talia Weinstein is a Medicine article available to read on EtoBox.

What is Electrolyte Imbalance in Anti-LGI1 Encephalitis: It Is Not All in Your Head about?

## Background and Objectives Antileucine-rich glioma-inactivated 1 (anti-LGI1) autoimmune encephalitis was first described in 2010 and is today the most common type of limbic encephalitis. During the course of the disease, 60%–88% of the patients develop hyponatremia. The etiology of the sodium disorder is unclear, often presumed to be the result of the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Other electrolyte abnormalities have not been reported in association with anti-LGI1 antibody encephalitis. Due to the presence of hypomagnesemia and hypophosphatemia in our patients, we set out to try to find the expression of LGI1 protein in the kidney as an explanation for these abnormalities. ## Methods We reviewed the medical files of all patients diagnosed with anti-LGI1 antibody encephalitis, at the Department of Neurology in the Tel Aviv Medical Center between January 2011 and December 2020, exploring for electrolyte abnormalities. Using tissue staining, Western blot, mass spectrometry, and RNA expression techniques, we tried to demonstrate the expression of LGI1 protein in the human kidney. ## Results We identified 15 patients diagnosed with anti-LGI1 antibod

Who reads Electrolyte Imbalance in Anti-LGI1 Encephalitis: It Is Not All in Your Head?

Author

Avi Gadoth; Michal Nisnboym; Yifat Alcalay; Asia Zubkov; Idit Schwartz; Doron Schwartz; Marana Abboud; Tamar Rubinek; Ofer Yossepowitch; Talia Weinstein

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2023

Field

Medicine (Health Sciences)