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Fluid shear stress activates YAP to promote epithelial–mesenchymal transition in hepatocellular carcinoma by Hongchi Yu; Jia He; Guanyue Su; Yuelong Wang; Fei Fang; Wenxing Yang; Kaiyun Gu; Naiyang Fu; Yunbing Wang; Yang Shen; Xiaoheng Liu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Fluid shear stress activates YAP to promote epithelial–mesenchymal transition in hepatocellular carcinoma about?
Epithelial–mesenchymal transition (EMT) mediated by fluid shear stress (FSS) in the tumor microenvironment plays an important role in driving metastasis of the malignant tumor. As a mechanotransducer, Yes‐associated protein (YAP) is known to translocate into the nucleus to initiate transcription of genes involved in cell proliferation upon extracellular biophysical stimuli. Here, we showed that FSS facilitated cytoskeleton rearrangement in hepatocellular carcinoma cells, which led to the release of YAP from its binding partner, integrin β subunit, in the cytomembrane. Moreover, we found that upregulation of guanine nucleotide exchange factor (GEF)‐H1, a microtubule‐associated Rho GEF, is a critical step in the FSS‐induced translocation of YAP. Nuclear YAP activated the expression of the EMT‐regulating transcription factor SNAI1, but suppressed the expression of N6‐methyladenosine (m^6^A) modulators; together, this promoted the expression of EMT‐related genes. We also observed that FSS‐treated HepG2 cells showed markedly increased tumorigenesis and metastasis in vivo. Collectively, our findings unravel the underlying molecular processes by which FSS induces translocation of YAP from
Who reads Fluid shear stress activates YAP to promote epithelial–mesenchymal transition in hepatocellular carcinoma?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Hongchi Yu; Jia He; Guanyue Su; Yuelong Wang; Fei Fang; Wenxing Yang; Kaiyun Gu; Naiyang Fu; Yunbing Wang; Yang Shen; Xiaoheng Liu
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)