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Can I read Feeding the Machine: Mechanisms of Proteasome-catalyzed Degradation of Ubiquitinated Proteins on EtoBox?
Feeding the Machine: Mechanisms of Proteasome-catalyzed Degradation of Ubiquitinated Proteins by Craig M Crews is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Feeding the Machine: Mechanisms of Proteasome-catalyzed Degradation of Ubiquitinated Proteins about?
The proteasome plays a role in a myriad of intracellular processes from cell-cycle control to antigen presentation. Central to these processes is the targeting of selected proteins for proteasomal degradation via their conjugation to ubiquitin. The mechanisms by which the ubiquitin-dependent proteasomal proteolysis occurs can be divided into four steps: first, substrate protein recognition by its cognate E3 ubiquitin ligase; second, polyubiquitinated protein substrate recruitment to the proteasome; third, protein substrate deubiquitination; and four, proteolytic chamber pore opening/substrate translocation followed by proteolysis. Recent advances include the identification of novel E3 ubiquitin ligase recognition determinants, a new isopeptidase activity, and a better understanding of how the proteasome's axial channels are gated.
Who reads Feeding the Machine: Mechanisms of Proteasome-catalyzed Degradation of Ubiquitinated Proteins?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Craig M Crews
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1367-5931)
- Published
- 2003
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)