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A secreted MIF homologue from Trichinella spiralis binds to and interacts with host monocytes by Shuaiqin Huang; Yun Qiu; Zhenrong Ma; Zhiming Su; Wenbin Hong; Heng Zuo; Xiang Wu; Yurong Yang is a Medicine article available to read on EtoBox.

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Trichinella spiralis is a very successful parasite capable of surviving in many mammal hosts and residing in muscle tissues for long periods, indicating that it must have some effective strategies to escape from or guard against the host immune attack. The functions of MIF have been studied in other parasites and demonstrated to function as a virulence factor aiding in their survival by modulating the host immune response. However, the functions of Trichinella spiralis MIF (TsMIF) have not been addressed. Here, we successfully obtained the purified recombinant TsMIF and anti-TsMIF serum. Our results showed that TsMIF was expressed in all the Trichinella spiralis developmental stages, especially highly expressed in the muscle larvae (ML) and mainly located in stichocytes, midgut, cuticle, muscle cells of ML and around intrauterine embryos of female adults. We also observed TsMIF could be secreted from ML and bind to host monocytes. Next, our data demonstrated that TsMIF not only stimulated the phosphorylation of ERK1/2 and cell proliferation by binding to the host cell surface receptor CD74, but also interacted with a host intracellular protein, Jab1, which is a coactivator of AP-1

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Author

Shuaiqin Huang; Yun Qiu; Zhenrong Ma; Zhiming Su; Wenbin Hong; Heng Zuo; Xiang Wu; Yurong Yang

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)