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Next-generation Sequencing of Cerebrospinal Fluid for the Diagnosis of Unexplained Central Nervous System Infections by Zhen Yu Li; Dan Dang; Hui Wu is a Medicine article available to read on EtoBox.

What is Next-generation Sequencing of Cerebrospinal Fluid for the Diagnosis of Unexplained Central Nervous System Infections about?

## Background: Central nervous system infections cause substantial morbidity and mortality in pediatric patients. however, in approximately half of the clinical cases, the etiology is unidentified. as an unbiased molecular diagnostic technology, next-generation sequencing is gradually being applied to investigate central nervous system infections. this review summarizes and critiques the literature on this new technology for etiologic identification of unexplained central nervous system infections in pediatric patients and discusses the future prospects for development of this technology in pediatrics. ## Methods: A comprehensive pubmed search was conducted of articles published from january 1, 2008, to june 26, 2020 in order to retrieve all available studies on this topic. other relevant articles were identified from recent reviews and the bibliographies of the retrieved full-text articles. ## Results: Among the 441 studies retrieved, 26 pediatric studies, comprising 15 case reports and 11 case series, used next-generation sequencing as a diagnostic tool. in these 26 studies, next-generation sequencing was performed on cerebrospinal fluid samples from 529 pediatric patients, and p

Who reads Next-generation Sequencing of Cerebrospinal Fluid for the Diagnosis of Unexplained Central Nervous System Infections?

Author

Zhen Yu Li; Dan Dang; Hui Wu

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0887-8994)

Published

2021

Language

EN

Field

Medicine (Health Sciences)