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A Comparative Study of Bolus Dose of Hypertonic Saline, Mannitol, and Mannitol Plus Glycerol Combination in Patients with Severe Traumatic Brain Injury by Harshad Patil; Rakesh Gupta is a Medicine article available to read on EtoBox.
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## Background: This prospective randomized controlled study compared the efficacy of an equiosmolar and isovolumetric dose of 3% hypertonic saline, 20% mannitol, and 10% mannitol plus 10% glycerol combination in reducing the raised intracranial pressure (icp) in patients with severe traumatic brain injury (tbi). ## Methods: A total of 120 patients of severe tbi with increased icp were randomized to receive an equiosmolar and isovolumetric dose of 3% hypertonic saline, 20% mannitol, and 10% mannitol plus 10% glycerol combination at a defined infusion rate, which was stopped when icp was 18 years, glasgow coma scale ≤8, and had sustained elevated icp of >20 mm hg for more than 5 minutes) were randomized during the study. all data were presented as mean (minimum-maximum). a one-way analysis of variance test was used to analyze the effect across the treatment group, and tukey's method was used for multiple comparisons. a paired t-test was employed to analyze the effect of the medication within each group. all 3 drugs decreased icp below 15 mm hg (p < 0.0001). the maximum change in icp occurred after a bolus dose of 3% hypertonic saline followed by 10% mannitol plus 10% glycerol combin
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- Author
- Harshad Patil; Rakesh Gupta
- Publisher
- Elsevier BV
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)