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Can I read Synthesis and Biological Evaluation of Nitrogen-containing Chalcones as Possible Anti-inflammatory and Antioxidant Agents on EtoBox?
Synthesis and Biological Evaluation of Nitrogen-containing Chalcones as Possible Anti-inflammatory and Antioxidant Agents by Babasaheb P. Bandgar; Sachin A. Patil; Rajesh N. Gacche; Balaji L. Korbad; Balwant S. Hote; Santosh N. Kinkar; Shivkumar S. Jalde is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis and Biological Evaluation of Nitrogen-containing Chalcones as Possible Anti-inflammatory and Antioxidant Agents about?
A novel series of nitrogen-containing chalcones were synthesized by Mannich reaction and were screened for anti-inflammatory related activities such as inhibition of cyclooxygenase-2 (COX-2), trypsin and beta-glucuronidase. The antioxidant potential was demonstrated using 1,1-diphenyl-2-picryl hydrazine (DPPH) radical scavenging activity. The results of the above studies shows that the compounds synthesized were found to be effective inhibitors of above pro-inflammatory enzymes, and were found to be possess moderate radical scavenging potential. Overall, the results of the studies reveal that the chalcones with N-methyl piperazine methyl and piperidine methyl substitution (4c, 3b, 4d, 6b) seems to be important for inhibition of beta-glucuronidase. Whereas the chalcones with piperidine methyl substitution (8b, 7b, 7c, 6c, 4b, 3c, 3b) were observed as effective inhibitors of COX-2, while the same compounds were found to be less reactive against COX-1 as compared to COX-2.
Who reads Synthesis and Biological Evaluation of Nitrogen-containing Chalcones as Possible Anti-inflammatory and Antioxidant Agents?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Babasaheb P. Bandgar; Sachin A. Patil; Rajesh N. Gacche; Balaji L. Korbad; Balwant S. Hote; Santosh N. Kinkar; Shivkumar S. Jalde
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)