Opening book details…
Can I read Presence of potent inhibitors of bacterial biofilm associated proteins is the key to Citrus limon’s antibiofilm activity against pathogenic Escherichia coli on EtoBox?
Presence of potent inhibitors of bacterial biofilm associated proteins is the key to Citrus limon’s antibiofilm activity against pathogenic Escherichia coli by Songeeta Singha; Rajendran Thomas; Abinash Kumar; Devarshi Bharadwaj; Jai N. Vishwakarma; Vivek Kumar Gupta is a Environmental Science article available to read on EtoBox.
What is Presence of potent inhibitors of bacterial biofilm associated proteins is the key to Citrus limon’s antibiofilm activity against pathogenic Escherichia coli about?
In an era of antibiotic resistance where natural antibiotic substitutes are considered essential, the antimicrobial and antibiofilm activities of Citrus limon extract on strains of pathogenic Escherichia coli isolated from pork were evaluated. The strains which form biofilms were more resistant (MIC 50 1⁄4 2.5 mgml À1 ) compared to non-biofilm forming strains (MIC 50 1⁄4 1.25 mgml À1 ). Use of C. limon extract at 20 mgml À1 concentration has resulted in inhibition of biofilm formation by 53.96%. Cyclobarbital, 5, 8-dimethoxycumarin, orotic acid and 3-methylsalicylhydrazide were the major phytochemicals in C. limon extract with highest docking affinities against the biofilm associated proteins in E. coli. The results of simulation studies have clearly illustrated the energy stability of the protein-ligand complexes. Absorption, distribution, metabolism, excretion and toxicity (ADMET) profiles revealed that the phytochemicals in C. limon could be used in the drug design studies to preferentially target the specific receptors to combat biofilms associated with E. coli.
Who reads Presence of potent inhibitors of bacterial biofilm associated proteins is the key to Citrus limon’s antibiofilm activity against pathogenic Escherichia coli?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Songeeta Singha; Rajendran Thomas; Abinash Kumar; Devarshi Bharadwaj; Jai N. Vishwakarma; Vivek Kumar Gupta
- Publisher
- Informa UK Limited
- Published
- 2023
- Language
- EN
- Field
- Environmental Science (Physical Sciences)