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Mortality in adult patients with solid or hematological malignancies and SARS-CoV-2 infection with a specific focus on lung and breast cancers: A systematic review and meta-analysis by Marco Tagliamento; Elisa Agostinetto; Marco Bruzzone; Marcello Ceppi; Kamal S. Saini; Evandro de Azambuja; Kevin Punie; C. Benedikt Westphalen; Gilberto Morgan; Paolo Pronzato; Lucia Del Mastro; Francesca Poggio; Matteo Lambertini is a Medicine article available to read on EtoBox.

What is Mortality in adult patients with solid or hematological malignancies and SARS-CoV-2 infection with a specific focus on lung and breast cancers: A systematic review and meta-analysis about?

## Background: A systematic review and meta-analysis was performed to estimate mortality in adult patients with solid or hematological malignancies and sars-cov-2 infection. ## Methods: A systematic search of pubmed, up to 31 january 2021, identified publications reporting the case-fatality rate (cfr) among adult patients with solid or hematological malignancies and sars-cov-2 infection. the cfr, defined as the rate of death in this population, was assessed with a random effect model; 95% confidence intervals (ci) were calculated. ## Results: Among 135 selected studies (n = 33,879 patients), the cfr was 25.4% (95% ci 22.9%-28.2%). at a sensitivity analysis including studies with at least 100 patients, the cfr was 21.9% (95% ci 19.1%-25.1%). among covid-19 patients with lung (n = 1,135) and breast (n = 1,296) cancers, cfr were 32.4% (95% ci 26.5%-39.6%) and 14.2% (95% ci 9.3%-21.8%), respectively. ## Conclusions: Patients with solid or hematological malignancies and sars-cov-2 infection have a high probability of mortality, with comparatively higher and lower cfrs in patients with lung and breast cancers, respectively.

Who reads Mortality in adult patients with solid or hematological malignancies and SARS-CoV-2 infection with a specific focus on lung and breast cancers: A systematic review and meta-analysis?

Author

Marco Tagliamento; Elisa Agostinetto; Marco Bruzzone; Marcello Ceppi; Kamal S. Saini; Evandro de Azambuja; Kevin Punie; C. Benedikt Westphalen; Gilberto Morgan; Paolo Pronzato; Lucia Del Mastro; Francesca Poggio; Matteo Lambertini

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)