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A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples by Yufan Fan; Fangyuan Wang; Fanbin Hou; Lai Wei; Guanghao Zhu; Dongfang Zhao; Qing Hu; Tao Lei; Ling Yang; Ping Wang; Guangbo Ge is a Chemistry article available to read on EtoBox.
What is A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples about?
Human serum albumin (HSA) has emerged as a pivotal biomarker and prognostic indicator for various human diseases. Real-time sensing and visual tracking of HSA in plasma or other biological systems will immensely facilitate the basic researchers and clinicians to better understand HSA-associated biological processes. Herein, a novel near-infrared (NIR) fluorescent probe (7-HTCF) was rationally constructed for light-up sensing and in-situ imaging of HSA in real samples, based on the principle of twisted intramolecular charge transfer (TICT). Under physiological conditions, 7-HTCF could be efficiently trapped by HSA to form a stable complex via binding on a non-drug binding site, while the complex emitted strong fluoresce signals around 670 nm. Further investigations demonstrated that 7-HTCF displayed a great combination of excellent selectivity and good chemical stability, as well as rapid fluorescent response and ultra-high sensitivity for HSA detection. Particularly, the newly developed light-up probe has been successfully utilized for quantitative detection of HSA in diluted plasma samples, while its readouts are hardly affected by the addition of therapeutic agents and herbal med
Who reads A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Yufan Fan; Fangyuan Wang; Fanbin Hou; Lai Wei; Guanghao Zhu; Dongfang Zhao; Qing Hu; Tao Lei; Ling Yang; Ping Wang; Guangbo Ge
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Chemistry (Physical Sciences)