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Vitamin K2 protects PC12 cells against Aβ (1-42) and H2O2-induced apoptosis via p38 MAP kinase pathway by Elham Hadipour; Zahra Tayarani-Najaran; Masoud Fereidoni is a Medicine article available to read on EtoBox.

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Alzheimer's is an age-related disease with a hallmark of progressive loss of memory formation followed by a damage in the brain function due to the neural degeneration and extracellular beta-amyloid (Aβ) plaques accumulation. This study examines the protective effects of vitamin K2 on toxicity induced by (Aβ) (1-42) and H 2 O 2 in PC12 cells as an appropriate model of Alzheimer's cell damage. PC12 cells pretreated with vitamin K2 (5-200 μM) for 4, 24 and 48 h, and exposed to either Aβ (25 μM) for 48 h or H 2 O 2 (150 μM) for 24 h. Then the protective, antioxidant and anti-apoptotic effects of vitamin K2 in PC12 cells were investigated. Vitamin K2 pretreatment (5-200 μM) significantly decreased the Aβ (1-42) and H 2 O 2 cytotoxicity. In addition, vitamin K2 could attenuate reactive oxygen species (ROS) level after exposure of cells to H 2 O 2 for 24 h and Aβ (1-42) for 48 h. Cell apoptosis significantly increased following application of Aβ (1-42) (25 μM) and H 2 O 2 (150 μM) compared to control. However, flow cytometry histograms of PI-stained cells after pretreatment with vitamin K2 (20 and 50 μM) showed significantly reduced apoptosis. Vitamin K2 increased the amount of glutathio

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Author

Elham Hadipour; Zahra Tayarani-Najaran; Masoud Fereidoni

Publisher

Informa UK Limited

Published

2018

Language

EN

Field

Medicine (Health Sciences)