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UVA- and UVB-induced changes in collagen and fibronectin biosynthesis in the skin of hairless mice by Benedicte Boyer; Annie Fourtanier; Patrick Kern; Jacqueline Labat-Robert is a Medicine article available to read on EtoBox.

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The modifications induced in hairless mouse skin by chronic UV irradiation were investigated. Skin explant cultures were used to study UVA- and UVB-induced changes occurring in interstitial collagen (type I and type III) and fibronectin biosynthesis. To study the long-term effects, albino hairless mice were irradiated with UVA radiation alone from two sources with different spectral qualities or with UVB. UVA and UVB radiation produced a significant increase in the ratio of type III to type I collagen (more than 100% for UVA-irradiated skin and about 60% for UVB-irradiated skin) accompanied by a significantly increased fibronectin biosynthesis (50% or more in all irradiated groups). Irradiation with either UVA or UVB alone had no significant effect on the total collagen synthesis and resulted in only a slight decrease in the total collagen content of the skin determined as hydroxyproline. This decrease was significant only in the case of the group irradiated with UVA (xenon) (decrease of 25%, expressed as micrograms of hydroxyproline per milligram wet weight). A significant decrease in collagen hydroxylation (expressed as radioactive hydroxyproline/radioactive hydroxyproline plus p

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Author

Benedicte Boyer; Annie Fourtanier; Patrick Kern; Jacqueline Labat-Robert

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1011-1344)

Published

1992

Language

EN

Field

Medicine (Physical Sciences)