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Homing imprinting and immunomodulation in the gut: Role of dendritic cells and retinoids by J. Rodrigo Mora is a Medicine article available to read on EtoBox.

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Lymphocyte migration is at the heart of chronic inflammatory ailments, including inflammatory bowel disease (IBD). Whereas naı ̈ve lymphocytes migrate to all secondary lymphoid organs, they are mostly excluded from nonlymphoid peripheral tissues. Upon activation, lymphocytes change their pattern of adhesion receptors and acquire the capacity to migrate to extralymphoid tissues. Antigenexperienced T cells are subdivided into different subsets based on their expression of homing receptors that favor their accumulation in specific tissues, such as the skin and the gut mucosa. B cells and antibody-secreting cells (ASC) also show tissue-tropism, which is somewhat correlated with the class of immunoglobulin that they produce. In fact, IgA-ASC are located in mucosal tissues, where they produce IgA, the main class of antibodies found in secretions. Although IgA-ASC are usually considered as a homogeneous pool of cells, those located in the small bowel have some unique migratory characteristics, suggesting that they are generated under different conditions as compared to IgA-ASC in other mucosal compartments. Foxp3 ϩ regulatory T cells (T REG ) can also exhibit tissue-specific migratory po

Who reads Homing imprinting and immunomodulation in the gut: Role of dendritic cells and retinoids?

Author

J. Rodrigo Mora

Publisher

John Wiley and Sons; Oxford University Press; Oxford University Press (OUP) (ISSN 1078-0998)

Published

2008

Language

EN

Field

Medicine (Health Sciences)