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Antibacterial terpenes from the oleo‐resin of Commiphora molmol (Engl.) by M. Mukhlesur Rahman; Mark Garvey; Laura J.V. Piddock; Simon Gibbons is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Two octanordammaranes, mansumbinone (1) and 3,4‐__seco__‐mansumbinoic acid (2), and two sesquiterpenes, __β__‐elemene (3) and T‐cadinol (4) have been isolated from the oleo‐resin of __Commiphora molmol__ (Engl.). The structures of these compounds were established unambiguously by a series of 1D and 2D‐NMR analyses. We have also unambiguously assigned all ^1^H and ^13^C NMR resonances for 2 and revised its ^13^C data. The crude extract of the oleo‐resin of __C. molmol__ displayed potentiation of ciprofloxacin and tetracycline against __S. aureus__, several __Salmonella enterica__ serovar Typhimurium strains and two __K. pneumoniae__ strains. The antibacterial activity of terpenes 1–4 was determined against a number of __Staphylococcus aureus__ strains: SA1199B, ATCC25923, XU212, RN4220 and EMRSA15 and minimum inhibitory concentration (MIC) values were found to be in the range of 4–256 μg/ml. The highest activity was observed by the __seco__‐A‐ring octanordammarane 2 with an MIC of 4 μg/ml against SA1199B, a multidrug‐resistant strain which over‐expresses the NorA efflux transporter, the major characterized antibiotic pump in this species. This activity compared favorably

Who reads Antibacterial terpenes from the oleo‐resin of Commiphora molmol (Engl.)?

Author

M. Mukhlesur Rahman; Mark Garvey; Laura J.V. Piddock; Simon Gibbons

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)