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Melatonin attenuates MPTP-induced dopaminergic neuronal injury associated with scavenging hydroxyl radical by Xue-June Li; Jing Gu; Shi-Duo Lu; Feng-Yan Sun is a Neuroscience article available to read on EtoBox.

What is Melatonin attenuates MPTP-induced dopaminergic neuronal injury associated with scavenging hydroxyl radical about?

To clarify the relationship between melatonin's hydroxyl radical (·OH) scavenging ability and its protective effect in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced neuronal injury, in the present study, the salicylate trapping method combined with high‐performance liquid chromatography (HPLC)‐electrochemical detection were used to measure the contents of dihydroxybenzoic acid (DHBA) and dopamine (DA) in brain tissues of C57BL/6 mice. Immunocytohistochemistry was used to detect tyrosine hydroxylase (TH)‐like positive staining neurons. Results show that MPTP treatment induced an increase in the content of DHBA and decrease in the level of DA as well as the number of TH positive stained neurons in the mouse brain. However, melatonin dose‐dependently inhibited the increase of DHBA levels in ventral midbrain tissues, the decrease of DA content and the loss of dopaminergic neurons. Moreover, the relationship between the changes of DHBA and DA levels in the brain of mice following MPTP and melatonin treatment showed a statistically significant negative correlation. Present results suggest that melatonin can ameliorate MPTP‐induced dopaminergic neuronal lesions probably, at

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Author

Xue-June Li; Jing Gu; Shi-Duo Lu; Feng-Yan Sun

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0742-3098)

Published

2002

Language

EN

Field

Neuroscience (Life Sciences)